Preclinical / early human

BPC-157

Also known as: Body Protection Compound 157, Bepecin, PL 14736 (related), stable gastric pentadecapeptide

Synthetic pentadecapeptide (derived from a sequence in human gastric juice protein)

Overview

BPC-157 is a 15-amino-acid peptide studied primarily in animal models, where it has shown effects on angiogenesis (new blood-vessel formation), tendon/ligament and gut healing, and modulation of inflammatory signaling. It is one of the most popular 'recovery' peptides among athletes, but the human evidence is very thin: a 2025 systematic review in the American Journal of Sports Medicine screened 544 articles and found only 1 clinical study met inclusion criteria, with the rest being preclinical animal models. As of early 2026 only about three small human pilot studies exist, and fewer than ~30 people have been studied across published human trials. It is not FDA-approved for any indication. Any claims about its benefits in humans should be treated as preliminary and unproven.

Commonly Reported Uses

These are uses commonly discussed or marketed by users and vendors — not a list of proven or approved benefits, and not a recommendation.

Tendon, ligament, and joint recovery (marketed claim; human evidence very limited)
Gut health and GI healing (marketed claim; mostly animal data)
General recovery from training or injury (marketed claim; unproven in controlled human trials)

What to Track

Data points you and your clinician might monitor. For observation only — not a diagnostic protocol.

Subjective — daily pain, stiffness, and recovery scores (especially for a tracked injury or joint)
Whoop — recovery score and HRV trend over a 30-day baseline
Labs — hs-CRP and other inflammatory markers if a clinician is monitoring
Range of motion / function — if rehabbing a specific injury, log progress
Sleep quality — Whoop SWS/REM trends

Sources & References

Quick Reference

Class: Synthetic pentadecapeptide (derived from a sequence in human gastric juice protein)
Evidence Level: Preclinical / early human
Reported Uses: 3 listed
Tracking Metrics: 5 suggested
Citations: 4 sources

Safety & Legal Notes

NOT FDA-approved for any human indication and has no Investigational New Drug (IND) status for general use. In the 2026 FDA compounding reclassification, BPC-157 was among peptides whose Category 2 nominations were withdrawn (moving off Category 2 effective April 23, 2026), and the FDA Pharmacy Compounding Advisory Committee was scheduled to review compounding eligibility at its July 23–24, 2026 meeting — but reclassification is NOT FDA approval, and at the time of writing it was not an approved or cleared-for-compounding drug for human use. Much of the market supply is sold as 'research use only' / not for human consumption. Considered a prohibited substance category in sport (growth-factor / peptide signaling); athletes should assume risk. Long-term human safety is not established. Consult a licensed clinician.

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Educational Disclaimer

EDUCATIONAL INFORMATION ONLY — NOT MEDICAL ADVICE. The information in this dataset is compiled from published research, regulatory filings, and reputable secondary sources for educational purposes. It does not constitute medical, legal, or professional advice and is not a substitute for consultation with a licensed healthcare provider. Many compounds listed here are NOT approved by the U.S. Food and Drug Administration (FDA) for human use; some are sold only as research chemicals, some are available only via compounding pharmacies with a prescription, and many are prohibited in competitive sport under the World Anti-Doping Agency (WADA) Prohibited List. Regulatory status changes frequently — the 2026 FDA compounding reclassification is an active, evolving situation and reclassification is NOT the same as FDA approval. Individual results vary. Always consult a qualified, licensed healthcare provider before starting, stopping, or modifying any peptide, supplement, or health protocol. Peptide OS is a personal data-tracking tool and an educational publisher; it does not sell, prescribe, dispense, or facilitate the sale of any drug or peptide.